We chose AKT 1/2 inhibitor as AKT inhibitor (AKTi) and confirmed its effects by examining phosphorylation statuses of AKT at S473 and its downstream FOXO1 at T24 in cultured HUVECs and ECs of MMTV-PyMT spontaneous breast tumour. The gene discussed is AKT1; the disease is breast neoplasm.