IRGM and neoplasm: The cGAMP-treated tumour ECs exhibited differentially expressed genes (DEGs) related to leucocyte recruitment and the interferon stimulation pathway, such as ACKR1, CCL5, CXCL9, CXCL10, IRF7, IRGM1, ISG15, OASL2, PHF11D, and SERPING1 (Fig. 4c).