TNF and neoplasm: Consistent with previous studies48,49, AKTi (10 μM) completely abolished TNFα-induced phosphorylation of AKT and FOXO1 in HUVECs (Fig. 9a), while i.p. AKTi (50 mg/kg of body weight) largely induced nuclear localization of FOXO1 in the tumour ECs (Fig. 9b).