Similar to those in WT mice, i.t. TNFα injection-induced tumour EC apoptosis by 15.9%, and co-treatment with TNFα and IFNγ further increased tumour EC apoptosis to 43.4% in STING KO mice (Supplementary Fig. 4c-e), While i.t. IFNγ alone did not induce significant apoptosis in LLC tumour, i.t. TNFα induced whole tumour cell apoptosis by 11.9% in STING KO mice. Here, STING1 is linked to neoplasm.