The cGAMP-treated tumour ECs exhibited differentially expressed genes (DEGs) related to leucocyte recruitment and the interferon stimulation pathway, such as ACKR1, CCL5, CXCL9, CXCL10, IRF7, IRGM1, ISG15, OASL2, PHF11D, and SERPING1 (Fig. 4c). The gene discussed is ISG15; the disease is neoplasm.