We demonstrate in multiple experiments that canonical TGFβ signaling is a central regulator of MYST1 expression and thus an important upstream regulator of autophagy in SSc: (I) Incubation with recombinant TGFβ decreased the mRNA and protein levels of MYST1 in cultured fibroblasts and induced autophagy. Here, KAT8 is linked to systemic sclerosis.