ARHGAP5 and breast cancer: qRT-PCR of 42 paired BC tissues showed that relative ARHGAP5 expression was negatively correlated with miR-516b-5p level (Fig. 4C), while following profiling of 17 predicted miRNA regulated genes in T24/UM-UC-3 versus circUBE2K knockdown T24/UM-UC-3 verified si-circUBE2K in BC cells uniquely reduced ARHGAP5 expression (Fig. 4D).