TIGIT and hereditary disease: Moreover, Cordeddu et al. [18] found that DRD3 joins with its adjacent genes (LOC107986115, ZNF80, TIGIT, MIR568, and ZBTB20) to constitute the DRD3-LOC107986115-ZNF80-TIGIT-MIR568-ZBTB20 locus which contributes to Primrose syndrome, a genetic disorder with intellectual disability and learning difficulties.