Our findings are in line with other association studies in the Taiwanese population from the Taiwan Biobank, indicating that physical activity may modulate cognitive aging by means of likely complex gene-physical activity interplays with the interleukin-12 related genes (such as IL12A, IL12B, and IL12RB2) [23], the DNA repair gene EXO1 [24], circadian clock genes (such as RORA and RORB) [22], and Alzheimer's disease-associated genes (such as SLC24A4) [25]. Here, CLOCK is linked to early-onset autosomal dominant Alzheimer disease.