First, we explored the associations between cognitive aging and the dopamine receptor-related loci, including the DRD1, NCAM1-TTC12-ANKK1-DRD2, DRD3-LOC107986115-ZNF80-TIGIT-MIR568-ZBTB20, DRD4, and DRD5-SLC2A9 loci. The gene discussed is DRD4; the disease is aging.