Here, we only selected one top SNP from each of NCAM1, TTC12, and ZBTB20. As illustrated in Table 3, there were significant two-way models concerning physical activity among rs11214442 in NCAM1, rs138333675 in TTC12, and rs77949732 in ZBTB20 (P < 0.001, < 0.001, and < 0.001, respectively), indicating potential physical activity and gene interactions between these genes and physical activity in regulating cognitive aging. This evidence concerns the gene ZBTB20 and aging.