Collectively, the experimental data in our study identified the high expression of hsa_circ_0000520 in both cervical cancer tissues and cells, yet silencing of hsa_circ_0000520 led to suppressed malignant cell proliferation and induced cell apoptosis, and the underlying mechanism was revealed to be dependent on miR-1296 upregulation and CDK2 downregulation. The gene discussed is CDK2; the disease is cervical carcinoma.