The mechanism of its anti-myeloma may be the inhibition of AKT phosphorylation and several AKT target genes including NF-κB, XIAP, cIAP and Cyclin D1, the suppression of MCL1 protein synthesis, and the induction of apoptosis in chronic lymphocytic leukemia cells. The gene discussed is AKT1; the disease is B-cell chronic lymphocytic leukemia.