Univariate analysis revealed that older age at breast cancer diagnosis (patients aged 40–49 years, P = 0.024 patients aged ≥60 years, P = 0.016), had ≥2 comorbidities (P = 0.001) and ER negative (P = 0.019) were associated with less likelihood of very substantial WHR increase. Here, ESR1 is linked to breast carcinoma.