The results showed that higher stromal fraction, and higher leukocyte fraction in the VEGF-high score subtype in both HPV-positive and HPV-negative HNSCC (Fig. 1A, P = 0.0002, P < 0.0001; P = 0.0144, P < 0.0001, respectively). This evidence concerns the gene VEGFA and head and neck squamous cell carcinoma.