In our group, we designed and synthesised a series of methoxy-, hydroxyl-, pyridyl-, or fluoro-substituted BAPs (Figure 1), which could significantly inhibit the activation of NF-κB signalling pathway by blocking the phosphorylation of IκBα, p65 and the nuclear translocation of NF-κB, thus exhibiting both anti-tumour and anti-inflammatory activities27–35. The gene discussed is NFKB1; the disease is neoplasm.