Moreover, both CD41a and CD49e expression increased after 3 days of BCR stimulation in the case of CLL patients, resulting in CD41a+ CLL B cells in four (Patient 2, 3, 4, 5) and CD49e+ CLL-B cells in six (Patient 2, 3, 4, 6, 7, 8) of the studied cases. This evidence concerns the gene ITGA5 and B-cell chronic lymphocytic leukemia.