Cep290 (120, 121) and Inpp5e (19), associated with syndromic ciliopathies that include obesity, and Bardet-Biedl syndrome (BBS) causal genes, Arl6, Bbs1, Bbs2, Bbs5, Bbs7 (122), were also present in these modules. The gene discussed is CEP290; the disease is obesity due to melanocortin 4 receptor deficiency.