ENTPD1 and neoplasm: Compared with the paired normal control (14.72% ± 13.21%), the frequency of tumor-infiltrating CD39+γδ Tregs was significantly increased in RSCRC (28.87% ± 14.94%), while it was decreased in LSCRC (11.08% ± 7.83%, P < 0.001, n = 35; Figure 1, A and B).