Approximately 15 days after symptoms, we detected a higher abundance of multiple cytokine-producing CXCR5+HLA-DR+ among CD4+ T cells and nucleocapsid-specific (NC-specific) CD8+ T cells, CXCR5+HLA-DR+ Tscms, and PD-L1+CXCR3+CD8+ Teffs in patients who recovered from COVID-19 than in patients who died. This evidence concerns the gene CD4 and COVID-19.