Upregulation of inflammatory genes indicating activation of myeloid and lymphoid cells included IL6, IL1b, CXCL8, CCL3, NLRP3, ATF3, OSM, CD83, GPR183, VCAN, CCR3, CXCL12, and CCL2. T2D patients showed a lower expression of inflammatory genes in EAT compared with overweight/obese (Figure 4, A and B, and Supplemental Figure 5B). Here, CXCL12 is linked to type 2 diabetes mellitus.