ADAMTS4 and coronary artery disorder: Interestingly, certain genes associated with CAD were dysregulated in obese EAT, such as HBEGF, ADAMTS1, and ADAMTS4 while the novel adipokine spexin (SPX), which regulates adipose tissue inflammation and was shown to protect cardiomyocytes from hypoxia-induced metabolic distress (22), was downregulated in EAT from both obese and diabetic patients.