Obesity induces a profound metabolic rewiring in EAT, with downregulation of genes associated with glucose metabolism (e.g., SLC24A, CS, GPT, OGDH, ACO2, GPI, LDHD) and lipid metabolism (e.g., GYS2, GPAT3, CRAT, FASN, ACADVL, DGAT1, DGAT2, NAT8L, SCD) as well as changes in genes related to adipogenesis (HES1, MXD3, NR4A2, RGS2, PPP1R15B, ADAMTS1, CEBPD, KDM7A). Here, SCD is linked to obesity due to melanocortin 4 receptor deficiency.