The nominal dichotome variables age above 65 years, male sex, underlying cirrhosis, Child–Pugh class C vs. A or B, BCLC stage C or D vs. A or B, ALBI grade 3 vs. grade 1 or 2, alpha-fetoprotein (AFP) > 400 ng/ml, sorafenib treatment, resection as HCC treatment and MDRO-colonization were included in this model. This evidence concerns the gene AFP and hepatocellular carcinoma.