Recent data have suggested that tuft cells can produce PGD2 (Bezençon et al., 2008; DelGiorno et al., 2020; Gerbe et al., 2016; Haber et al., 2017), provoking the hypothesis that tuft cells are a source of PGD2 that could act on IECs during helminth infection. This evidence concerns the gene HPGDS and helminthiasis.