Unexpectedly, despite the known pro-inflammatory role for CRTH2 (Oyesola et al., 2020a; Tait Wojno et al., 2015), mice deficient in CRTH2 and mice that lacked CRTH2 only in the radioresistant compartment had enhanced worm expulsion, largely intact Type 2 cytokine responses, and increased goblet cell hyperplasia compared with WT control mice following infection with the helminth Nippostrongylus brasiliensis. Here, PTGDR2 is linked to infection.