Helminth infection has a wide array of effects on IECs, reshaping the Lgr5+ compartment, increasing IEC proliferation, inducing villus atrophy and crypt hyperplasia, increasing the pace at which cells move through the epithelial escalator, and skewing to secretory lineage differentiation, all components of the weep and sweep response that expels helminths (Artis and Grencis, 2008; Cliffe et al., 2005; Gerbe et al., 2016; Hasnain et al., 2012; Howitt et al., 2016; McDermott et al., 2005; McKenzie et al., 1998; Nusse et al., 2018; von Moltke et al., 2016). This evidence concerns the gene LGR5 and helminthiasis.