ICD involves the cell surface exposure of calreticulin (CRT), release of DAMPs-related high mobility group box1 (HMGB1) and autophagy-dependent ATP release, which together, leads to the antigen uptake and presentation of DC cell, and then activates the CD8+ TILs to play the anti-tumor role [130,131]. The gene discussed is HMGB1; the disease is neoplasm.