The mechanisms underlying pro-tumor role of Foxp3+ Tregs included (i) down-regulation of Notch pathway [56]; (ii) direct suppression via cell-cell contact and indirect suppression via secretion of anti-inflammatory mediators such as interleukins (IL-4, IL-5 and IL-10) [57,58,59]; (iii) decreased secretion of cytokine IFN-γ and IL-17 and activation of STAT1/STAT3 [59]. This evidence concerns the gene FOXP3 and neoplasm.