Recently it was published that 10 HUB genes (SPP1, POSTN, COL1A2, FN1, IGFBP3, APP, MMP3, MMP13, CXCL8, and CXCL12) were differentially expressed in HNSCC [21]. The gene discussed is IGFBP3; the disease is head and neck squamous cell carcinoma.