Moreover, 10 of the differentially expressed protein coding genes (MMP1, MMP9, COL1A2, GREM1, POSTN, FMOD, THSB, DCN, VCAN, CTSK, and IVL) revealed by microarray analysis of tumor cells cultured in spheroids were selected for verification by qRT-PCR. Here, COL1A2 is linked to neoplasm.