For 22 patients in cohort 1 (n = 15) and 2 (n = 7), we evaluated whether mutant EGFR AF and copy numbers at baseline, day 7, day 21/28, and day 42/56 measured by ddPCR were associated with PFS on osimertinib (patients in cohort 3 were excluded from this analysis because they presented with osimertinib-resistant disease). This evidence concerns the gene EGFR and atrial fibrillation.