The mutation profile of MYC/BCL2 DHLs is intermediate between BL and shows mutations affecting ID3, CCND3, MYC, and TCF3, and DLBCL of the GCB type, which harbors mutations in BCL2, EZH2, CREBBP, EP300, MEF2B, and SGK1 [58]. The gene discussed is BCL2; the disease is diffuse large B-cell lymphoma.