Firstly, molecular and protein analyses failed to reveal an ALK gene rearrangement, but later studies demonstrated that most ALK+ DLBCL harbor the t(2;17)(p23;q23) translocation, which results in the fusion of the ALK gene at chromosome band 2p23 and the clathrin gene (CLTC) at 17q2.clathrin (CLTC), in 85–90% of the cases [201,202], and more rarely, the t(2;5)(p23;q35), which results in the nucleophosmin (NPM)-ALK fusion gene, which characterizes up to 75% of the anaplastic large T cell lymphomas (ALCL) [203,204]. This evidence concerns the gene NPM1 and anaplastic large cell lymphoma.