Another study showed that when monocytes are stimulated with EVs derived from oral squamous cell carcinoma (OSCC), the uptake of these EVs by monocytes leads to NF-κB activation and the generation of a pro-inflammatory environment, which was characterized by elevated levels of IL-6, monocyte chemoattractant protein 1 (MCP1), prostaglandin E2 (PEG2) and MMP9 [157]. The gene discussed is CCL2; the disease is oral cavity squamous cell carcinoma.