For instance, glycosylphosphatidylinositol (GPI) anchored EV proteins such as decay-accelerating factor (known as CD55) were used by Kooijmans et al. [244] to attach anti-epidermal growth factor receptor (EGFR) nanobodies to EVs and thereby improve targeting to EGFR overexpressing epidermoid carcinoma A431 cells. This evidence concerns the gene EGFR and squamous cell carcinoma.