Specifically, in some cancers, such as bladder, gastric, and non-small cell lung cancer, it has been shown that this increase in proliferation is through the activation of signaling pathways involving phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) or AMP-activated protein kinase (AMPK)/extracellular signal-regulated kinases (ERK) [62,90,91,92]. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.