In breast cancer, EVs from the highly metastatic cell line MDA-MB-231 containing caveolin-1 enhanced the migration and invasion in vitro of the less metastatic breast cancer cell line T47-D lacking caveolin-1 [14], providing evidence for the importance of caveolin-1 in the genesis of exosomes with elevated malignant potential. This evidence concerns the gene CAV1 and breast carcinoma.