CDKN1C and colorectal carcinoma: To clarify whether miR-92b-3p regulated the sensitivity of CRC cells to chemotherapeutic drugs by inhibiting CDKN1C, changes in cell sensitivity to chemotherapeutic drugs were examined using the CCK8 assay after overexpression of miR-92b-3p and CDKN1C. Interestingly, the co-expression of CDKN1C and miR-92b-3p attenuated the inhibitory effect of miR-92b-3p on CDKN1C expression (Figure 5A) and the desensitization effect on HCT8 cells (Figure 5B and Table 3).