It was already known that CDKN1C was an imprinted gene (maternally expressed gene) located on human chromosome 11p15.5, and that the expression was epigenetically regulated and usually considered as a tumor suppressor gene involved in tumorigenesis, with reduced expression or inactivation in a variety of tumors, such as ovarian, lung, and bladder cancer [36]. The gene discussed is CDKN1C; the disease is urinary bladder cancer.