Kinases that would be of interest, as targeting possibilities for metastasis in general in breast cancer would be those that are activated on the FDMs vs. plastic, and in the 4T1, such as ITK, IRR, PKCα/δ/γ/φ/ε, PKG1/2, Pim1, PKD1, RSK1, IKKα/β, ANP, CK1, MAPKAPK2/3, Akt1/2, CamK4, p7056kβ, SGK, PDGFRα/β, FGFR, pKA, and PRKX. The gene discussed is PIM1; the disease is breast cancer.