Kinases that would be of interest, as targeting possibilities for metastasis in general in breast cancer would be those that are activated on the FDMs vs. plastic, and in the 4T1, such as ITK, IRR, PKCα/δ/γ/φ/ε, PKG1/2, Pim1, PKD1, RSK1, IKKα/β, ANP, CK1, MAPKAPK2/3, Akt1/2, CamK4, p7056kβ, SGK, PDGFRα/β, FGFR, pKA, and PRKX. This evidence concerns the gene RPS6KA1 and breast carcinoma.