TNFRSF8 and Huntington disease: In our study, we detected the presence of TNF receptors superfamily: The sTNF-R1, sTNF-R2, TNFRSF8, and TNFRSF13B to be significantly upregulated in metastatic UM patient-derived exosomes when compared to primary patients, except sTNF-R2, to the HD group.