IGF1 and cancer: Angi et al. have analyzed the secretome of low- and high-risk UM cell lines derived from primary tumours and they showed their involvement in signalling pathways associated with remodelling of extracellular matrix, cell adhesion, activation of hepatic fibrosis/hepatic stellate cell, EIF2, Rho and IGF-1 signalling, and cancer cell migration/invasion [31].