STAT3 and breast cancer: Khanh et al. demonstrated that in patients with type 2 diabetes mellitus, ADMSCs-derived EVs were highly associated with migration and metastasis of breast cancer cells through epidermal growth factor receptor 1 (EGFR-1)/IL-6 mediated activation of the Janus kinase (JAK)/signal transducers and activators of transcription (STAT-3) pathway [73].