Indeed, a number of genetic zebrafish models have provided important data on the disease mechanisms of several leukodystrophies (Pant et al., 2019; Strachan et al., 2017), including the involvement of microglia in the early disease pathology of CSF1R-related leukodystrophy (Oosterhof et al., 2018, 2019) and RNASET2-related leukodystrophy (Haud et al., 2011; Hamilton et al., 2020; Weber et al., 2020), and the identification of possible therapeutic targets for the treatment of X-ALD (Raas et al., 2021). Here, RNASET2 is linked to leukodystrophy.