High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, so called double-hit and triple-hit (DH/TH) lymphomas, are defined in the 2016 World Health Organization (WHO) classification as a new diagnostic category and includes a subset of tumors with DLBCL morphology [7]. The gene discussed is BCL2; the disease is diffuse large B-cell lymphoma.