KLK3 and posterior cortical atrophy: A pivotal study published by Tomlins et al. [43] in 2016 indicated the high diagnostic value of MPS, AUC = 0.751 for detecting PCa on biopsy and AUC = 0.772 for detecting clinically significant PCa (defined as Gleason ≥ 7), which was significantly better than for PSA alone (AUC = 0.651) (Table 3).