For PCA3 score < 20 and PSA < 4 ng/mL 8% of men would have avoided biopsies, while 9% of cancer (non-HG) have been underdiagnosed. For only PCA3 score < 20 46% biopsies would have been avoided, while missing 12% of cancers (3% HG [14]). Here, PCA3 is linked to cancer.