AGO4 and glioblastoma: In glioblastoma-derived cell lines and glioblastoma tumor samples, the methylation of mature miR-181a-5p by the DNMT3A/AGO4 complex inhibits the recognition of its target mRNA BIM, a proapoptotic gene, also known as B-cell chronic lymphocytic leukemia/lymphoma (Bcl-2)-like 11 (BCL2L11) [170].