Regarding specific histotypes with frequent TP53 mutations, there was a non–significant trend towards increased response in leiomyosarcomas: ORR was 39%, 30%, and 46%, in TP53 WT, deleted and mutated leiomyosarcomas (OR = 1.35; 95%CI = 0.31–5.84; p = 0.69; Table S6). This evidence concerns the gene TP53 and leiomyosarcoma.