In initially localized sarcomas, first recurrence was more frequently metastatic than loco-regional in TP53 altered sarcomas compared to TP53 wild type sarcomas (p = 0.004): there were three local (7.3%) and 38 (93%) metastatic recurrences in the TP53 mutated sarcomas, whereas there were 36 (30%) local and 85 (70%) metastatic relapses in the TP53 wild type sarcomas. Here, TP53 is linked to sarcoma.