Overall, there is an overlap between the spectrum of gene mutations observed in our cohort and the significantly mutated genes reported in The Cancer Genome Atlas (TCGA) 2012 breast cancer cohort [36], except for ITGB2 and SPEN, which have not been reported as significantly mutated in the TCGA cohort and MAP2K4, that did not show any mutations in our cohort. The gene discussed is ITGB2; the disease is breast carcinoma.