Hence, we considered “gene driver free” MSS CRC patients without mutations in KRAS, NRAS and BRAF, LAC patients without EGFR, KRAS, NRAS, BRAF and ERBB2 mutations and with no ALK, ROS1 and RET fusions and MEL patients without BRAF and NRAS mutations. This evidence concerns the gene BRAF and colorectal carcinoma.