Likewise, in 77 patients evaluable for progression, Boyle et al. identified KRAS mutations associated with shorter TTP [24], suggesting that the lack of association with prognosis that they have in MM highlights their important role in the transition from asymptomatic to symptomatic stages of the disease, mediated by impacting on cell-cycle progression and promoting a clonal sweep. Here, KRAS is linked to Miyoshi myopathy.