In particular, in a subset of 85 untreated patients in clinical trial setting before progression to MM, MYC aberrations (translocations or amplifications), MAPK pathway mutations, DNA repair pathway alterations, t(4;14), del(1p), del(8p), biallelic deletion events and APOBEC-associated mutations were associated with a shorter TTP [8]. The gene discussed is MYC; the disease is Miyoshi myopathy.