TSC1 and neoplasm: In the CA-Pheo patients, germline mutations were predicted in SDHB, RET, VHL, and MEN1. For the CA-Para group, predicted germline tumor predisposition gene mutations predominantly involved the SDHA/B genes with other rare germline mutations in BRD4, FLCN, TSC1, CHEK2, TNKS, MUTYH, FAT3, PTEN, TNKS, IDH2, FANCA, TET2, and VHL.