In addition, for IAV infections in particular, varied efficiency of the CD8+ T cell response throughout the course of infection, their early antigen-specific and lung-resident responses (Yoon et al., 2007; McGill and Legge, 2009; Keating et al., 2018), and the balanced consequences on viral loads and host pathology have not yet been investigated in detail. The gene discussed is CD8A; the disease is infection.