Interestingly, we showed that EIF3S5 interacts with both LAMR1 and E protein, and further demonstrated that EIF3S5 is the deubiquitination enzyme required for LAMR1-mediated ZIKV E protein deubiquitination as well as the antiviral effects of LAMR1 against ZIKV infection. Here, EIF3F is linked to Zika virus infectious disease.