Beyond a physiological role in regulating energy balance, the cannabinoid transduction cascade may have a pathophysiological function to stimulate insulin-dependent lipid deposition through enhanced insulin output in response to increased levels of peripheral 2-AG, as seen in obesity [72], which implies that a dysregulated endocannabinoid system in the adipocytes and β-cells likely contributes to hyperlipidemia, hypoadiponectinemia, and hyperinsulinemia in obesity [72]. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.