Both Bv8 and Mmp9 were expressed at a higher level in JUNB-deficient neutrophils but upregulation of Mmp9 was neither apparent in macrophages isolated from the tumor nor alveolar or interstitial macrophages from lungs at the initial metastatic stage (Fig. 5a and b, Online Resource Fig. 5b). The gene discussed is PROK2; the disease is neoplasm.