In light of this, we found a positive correlation of SLC1A5 and TALDO1 expression with proliferation-associated genes, including CCND1, CCNA2, CCNB1 and MKI67. Therefore, our finding suggests key roles for both SLC1A5 and TALDO1 in regulating cellular proliferation within the cell cycle of luminal breast cancer, which may initiate molecular mechanisms that affect cell response to endocrine therapy. This evidence concerns the gene SLC1A5 and breast cancer.