CA2 and COVID-19: Pancreatic tissues from COVID-19 patients showed perturbation with upregulation of key ductal genes such as KRT19, CA2 and CFTR. Increased KRT19 expression is associated with pancreas-specific intracellular stress in patients with poor prognosis of pancreatic ductal adenocarcinoma (PDAC) (Yao et al., 2017).