Although CXCL12 seems to promote tumor invasion, proliferation, angiogenesis, epithelial to mesenchymal transition and metastasis in pancreatic cancer (Righetti et al., 2019), its roles seem to be pleiotropic, and this could be due to the presence of at least six CXCL12 splicing isoforms, each with different roles (Righetti et al., 2019). This evidence concerns the gene CXCL12 and neoplasm.