The present study aimed to evaluate the frequency of and the association between DRB5*01--DRB1*1501+-DQB1*0602+, DRB5*01+-DRB1*1501+-DQB1*0602-, DRB5*01+-DRB1*1501+-DQB1*0602+, DRB5*01+-DQB1*0602-, DRB5*01--DQB1*0602-, DRB5*01+-DQB1*0602+, and DRB5*01--DQB1*0602+ haplotypes and to assess the effect of the HLA-DR2 haplotype on MS susceptibility in Khuzestan Province. This evidence concerns the gene HLA-DRB5 and myeloid sarcoma.