In contrast, in two other reports (134, 135), a different Tlr4 mutant mouse strain, B6.B10ScN-Tlr4lps-del/JthJ, was shown to succumb to infection with the mouse-adapted A/WSN/33 strain and also to the PR8 strain of influenza, leading to the conclusion that loss of TLR4 did not protect against influenza-induced lethality (135). This evidence concerns the gene TLR4 and influenza.