For example, the progenitor strain, C57BL/10ScN, and its successor, C57BL/10ScCR, both express the deletion in Tlr4; however, the latter strain possesses an additional point mutation in the gene encoding the IL-12Rβ2, causing it to express a distinct phenotype affecting IFN-γ production in response to infection (138). This evidence concerns the gene TLR4 and infection.