In an extensive series of studies, Vonderheide and colleagues first demonstrated that CD40 stimulation in combination with gemcitabine induced T cell-independent remodeling of the tumor stroma in humans, in particular inducing tumor-infiltrating macrophages to become tumoricidal and deplete the tumor stroma, which is important in pancreatic cancer [18–20]. The gene discussed is CD40; the disease is pancreatic neoplasm.