EIF2AK3 and melanoma: However, the PERK inhibitor GSK2606414 or a combination of GSK2606414 with PLX4032 significantly inhibited Sk-mel28R and WLH6215R melanoma growth in mice compared with their vehicle control (Fig. 6a, b) and reduced the weight of resistant Sk-mel28R and WLH6215R melanomas significantly (Fig. 6c, d).