Furthermore, we verified a significant reduction in plasma Glu levels on Days 3 and 7 post melanoma implantation in the BGS treated group (Fig. 1B), compared to the naive mice or to vehicle-treated mice implanted with RET melanoma cells (naïve mice: 19.98 ± 0.9; vehicle-control group: day 3 23.25 ± 1.5, day 7 25.62 ± 2.5; BGS group: day 3 12.71 ± 1.3 μM, day 7 11.55 ± 1.6 μM, p˂0.001). Here, RET is linked to melanoma.