In addition, we have shown a high amount of IFN-γ production by CD8+ TILs, which is in agreement with other studies which claim the degree of CD3+ CD8+ proliferating TILs in melanoma tumor lesion correlates with the presence of IFN-γ signature, which is associated with intuitive ability in remission of primary lesions29. This evidence concerns the gene CD8A and neoplasm.