HIF1A and acute myeloid leukemia: As shown in Supplementary Fig. 2, the OS of AML patients with higher HIF-1a levels were not significantly higher than that of AML patients with lower HIF-1a levels, both in TARGET (Supplementary Fig. 2A, P > 0.05) and in GEO (Supplementary Fig. 2B, P > 0.05), suggesting that HIF-1a did not have a significant correlation with the OS of AML patients.