While in the functional enrichment based on Reactome database (Fig. 4c), 7 pathways came out as the significantly influenced, including cellular respiratory pathways like electron transport, tricarboxylic acid (TCA) cycle, complex I biogenesis, as well as intraflagellar transport and cancer-related pathways (regarding transforming growth factor (TGF)-beta, zeta-chain-associated protein (ZAP)-70). This evidence concerns the gene ZAP70 and cancer.