PTPRC and pancreatitis: In PACIRKO mice, there was a potentiation of POA/ETOH-induced pancreas wet/dry weight ratio (58 ± 4% vs 22 ± 2% in IRlox/lox mice; Fig. 4a), pancreatic tissue cytokine expression (Fig. 4b–e), histological features of pancreatitis (H&E; Fig. 4f–k) and CD45-positive staining (Fig. 4h–m).