We have shown in previous publications that expression of several of the genes in these clusters (THBS1, COMP, ADAM12, and CTGF) correlate highly and statistically significantly with the MRSS42, so the observation that these genes cluster together in bulk RNA-seq analysis and their co-expression in our scRNA-seq dataset in the transition of healthy SFPR2hi fibroblasts to SSc SFRP2hi fibroblasts (THBS1) and myofibroblasts (ADAM12 and CTGF) is consistent with the roles of these SSc fibroblast populations in driving clinical disease. The gene discussed is THBS1; the disease is systemic sclerosis.