Several genes regulated in SSc myofibroblasts are reciprocally regulated compared to SM22 promoter tdTomato sorted wound myofibroblasts, as the wound heals and the fibroblasts lose SMA expression61 (Supplementary Data 9): TNC, SERPINE2, IGFBP3 (increased in SSc and early SMA+ wound myofibroblasts), and WIF1 (decreased in SSc and late SMA+ wound myofibroblasts). This evidence concerns the gene TNC and systemic sclerosis.